1,1,1-Trifluoro-2,4-pentanedione → 2,2,2-Trifluoro-1-(2-methyl-4-thiophen-2-yl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-b]pyridin-3-yl)-ethanone

HRID 133497

Reaction equation

[NH2:1][C:2]1[S:6][C:5]2[CH2:7][CH2:8][CH2:9][CH2:10][C:4]=2[C:3]=1[C:11]([C:13]1[S:14][CH:15]=[CH:16][CH:17]=1)=O.[F:18][C:19]([F:27])([F:26])[C:20](=[O:25])[CH2:21][C:22](=O)[CH3:23]>C(O)(=O)C.S(=O)(=O)(O)O>[F:18][C:19]([F:27])([F:26])[C:20]([C:21]1[C:11]([C:13]2[S:14][CH:15]=[CH:16][CH:17]=2)=[C:3]2[C:4]3[CH2:10][CH2:9][CH2:8][CH2:7][C:5]=3[S:6][C:2]2=[N:1][C:22]=1[CH3:23])=[O:25]

Participants

Conditions

Temperature: 100 °C

Procedure

To a stirred solution of 50 mg (0.19 mmol) (2-amino-4,5,6,7-tetrahydro-benzo[b]thiophen-3-yl)-thiophen-2-yl-methanone in 1.5 ml acetic acid was added 0.024 ml (0.20 mmol) of 1,1,1-trifluoro-pentane-2,4-dione and one drop of sulfuric acid. The mixture was then stirred at 100° C. for 10 minutes in a microwave and then concentrated in vacuo. Flash chromatography (heptane/ethyl acetate 9:1) afforded 17 mg (23%) 2,2,2-trifluoro-1-(2-methyl-4-thiophen-2-yl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-b]pyridin-3-yl)-ethanone as an orange oil. ES-MS m/e (%): 382 (M+H+, 100).

Workup

concentrationconcentrated in vacuo

Sources & evidence

ORD record: ord-2450389431d6409cb2971bceac54a2c2
Source dataset: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07390903B2

Linked notes

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