5-Methyl-2-pyrazinecarboxylic acid → 5-(2-Difluoromethoxypyridin-3-yloxy)-6-(6-methanesulfonyl-pyridin-3-yloxy)-2-(5-methyl-pyrazin-2-yl)-1H-benzimidazole

HRID 13373

Reaction equation

HRID 13373 reaction equation
[F:1][CH:2]([F:37])[O:3][C:4]1[C:9]([O:10][C:11]2[C:25]([O:26][C:27]3[CH:28]=[N:29][C:30]([S:33]([CH3:36])(=[O:35])=[O:34])=[CH:31][CH:32]=3)=[CH:24][C:14]3[NH:15][C:16]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=4)=[N:17][C:13]=3[CH:12]=2)=[CH:8][CH:7]=[CH:6][N:5]=1.CC1[N:40]=CC(C(O)=O)=NC=1>>[F:1][CH:2]([F:37])[O:3][C:4]1[C:9]([O:10][C:11]2[C:25]([O:26][C:27]3[CH:28]=[N:29][C:30]([S:33]([CH3:36])(=[O:34])=[O:35])=[CH:31][CH:32]=3)=[CH:24][C:14]3[NH:15][C:16]([C:18]4[CH:23]=[N:40][C:21]([CH3:22])=[CH:20][N:19]=4)=[N:17][C:13]=3[CH:12]=2)=[CH:8][CH:7]=[CH:6][N:5]=1

Participants

3

Reactant 2

HCID 1228315-Methyl-2-pyrazinecarboxylic acidHCID 231453475-(2-Difluoromethoxy-pyridin-3-yloxy)-6-(6-methanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1h benzimidazole

Product 1

HCID 231456805-(2-Difluoromethoxypyridin-3-yloxy)-6-(6-methanesulfonyl-pyridin-3-yloxy)-2-(5-methyl-pyrazin-2-yl)-1H-benzimidazole

Procedure

The entitled compound was obtained as a pale yellow solid in the same method as in Example 38 or in accordance with the method or by combining it with an ordinary method but using 4-(2-difluoromethoxy-pyridin-3-yloxy)-5-(6-methanesulfonyl-pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 215 and 5-methyl-pyrazine-2-carboxylic acid.

Workup

  1. customThe entitled compound was obtained as a pale yellow solid in the same method as in Example 38 or in accordance with the method

Sources & evidence

ORD record
ord-c97b065a87164576b8794dca243df239
Source dataset
uspto-grants-2010_06
Patent number
US07728025B2

Linked notes

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