Water → n-(2-Fluoro-4-hydroxyphenyl)acetamide

HRID 133732

Reaction equation

HRID 133732 reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][C:10]=1[F:16].O>C(O)(=O)C>[F:16][C:10]1[CH:11]=[C:12]([OH:15])[CH:13]=[CH:14][C:9]=1[NH:8][C:5](=[O:7])[CH3:6]

Participants

5

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 27359194-Amino-3-fluorophenol

Product 1

HCID 190616n-(2-Fluoro-4-hydroxyphenyl)acetamide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Acetic anhydride (1.3 ml, 13.8 mmol) was added dropwise to a solution of 4-amino-3-fluorophenol (1.0 g, 7.9 mmol) in acetic acid (25 ml) at room temperature. The reaction mixture was stirred at room temperature for 2 h and water (2 ml) was added and the stirring was continued for 30 minutes at room temperature. The mixture was evaporated to dryness in vacuo. The yield of the crude product was 1.3 g (100%) and it was used without further purification.

Workup

  1. waitthe stirring was continued for 30 minutes at room temperature
  2. customThe mixture was evaporated to dryness in vacuo
  3. customwas used without further purification

Sources & evidence

ORD record
ord-87286c2ade0143448a517e8f0fd7426b
Source dataset
uspto-grants-2008_06
Patent number
US07390923B2

Linked notes

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