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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 13375Generated: October 26, 2026

2,3-Difluorobenzonitrile → 5-(2-Fluoro-6-cyanophenoxy)-2-pyridin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

https://huagongshe.com/reaction/13375

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,3-DifluorobenzonitrileHCID 88935—
ReactantHCID 178477648HCID 178477648—
Product5-(2-Fluoro-6-cyanophenoxy)-2-pyridin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazoleHCID 11318274—

Reaction Steps

The entitled compound was obtained as a pale green solid in the same method as in Example 251 or in accordance with the method or by combining it with an ordinary method but using 5-hydroxy-2-pyridin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole obtained in Example 397 and 1,2-difluoro-3-cyano-benzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07728025B2
Source datasetuspto-grants-2010_06
ORD IDord-95406735296e4bf7a458cd7b46629edf
Source noteuspto-grants-2010_06