2,3-Difluorobenzonitrile → 4-(2-cyano-6-fluoro-phenoxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1H-benzimidazole

HRID 13379Notes

Reaction equation

HRID 13379 reaction equation
[OH:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=3)[NH:7][C:6]=2[CH:5]=[C:4]([O:17][C:18]2[CH:19]=[N:20][C:21]([S:24]([CH2:27][CH3:28])(=[O:26])=[O:25])=[CH:22][CH:23]=2)[CH:3]=1.F[C:30]1[C:37]([F:38])=[CH:36][CH:35]=[CH:34][C:31]=1[C:32]#[N:33]>>[C:32]([C:31]1[CH:34]=[CH:35][CH:36]=[C:37]([F:38])[C:30]=1[O:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=3)[NH:7][C:6]=2[CH:5]=[C:4]([O:17][C:18]2[CH:19]=[N:20][C:21]([S:24]([CH2:27][CH3:28])(=[O:25])=[O:26])=[CH:22][CH:23]=2)[CH:3]=1)#[N:33]

Participants

3

Reactant 2

HCID 889352,3-DifluorobenzonitrileHCID 1356979674-hydroxy-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1H-benzimidazole

Product 1

HCID 231453574-(2-cyano-6-fluoro-phenoxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1H-benzimidazole

Procedure

The entitled compound was obtained in the same method as in Example 251 (step 2) or in accordance with the method or by combining it with an ordinary method but using 4-hydroxy-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1H-benzimidazole and 2,3-difluorobenzonitrile.

Workup

  1. customThe entitled compound was obtained in the same method as in Example 251 (step 2) or in accordance with the method

Sources & evidence

ORD record
ord-2d5045f790684d51b8cb06ed1862fd64
Source dataset
uspto-grants-2010_06
Patent number
US07728025B2

Reaction notes

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