2,4-Difluorobenzonitrile → 4-(2-Cyano-5-fluoro-phenoxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyrazin-2-yl-1H-benzimidazole

HRID 13380

Reaction equation

HRID 13380 reaction equation
[C:1]([C:3]1[CH:36]=[CH:35][CH:34]=[C:33](F)[C:4]=1[O:5][C:6]1[C:14]2[N:13]=[C:12]([C:15]3[CH:20]=[N:19][CH:18]=[CH:17][N:16]=3)[NH:11][C:10]=2[CH:9]=[C:8]([O:21][C:22]2[CH:23]=[N:24][C:25]([S:28]([CH2:31][CH3:32])(=[O:30])=[O:29])=[CH:26][CH:27]=2)[CH:7]=1)#[N:2].[F:38]C1C=C(F)C=CC=1C#N>>[C:1]([C:3]1[CH:36]=[CH:35][C:34]([F:38])=[CH:33][C:4]=1[O:5][C:6]1[C:14]2[N:13]=[C:12]([C:15]3[CH:20]=[N:19][CH:18]=[CH:17][N:16]=3)[NH:11][C:10]=2[CH:9]=[C:8]([O:21][C:22]2[CH:23]=[N:24][C:25]([S:28]([CH2:31][CH3:32])(=[O:30])=[O:29])=[CH:26][CH:27]=2)[CH:7]=1)#[N:2]

Participants

3

Reactant 2

HCID 775452,4-DifluorobenzonitrileHCID 113182844-(2-Cyano-6-fluoro-phenoxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyrazin-2-yl-1H-benzimidazole

Product 1

HCID 231457744-(2-Cyano-5-fluoro-phenoxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyrazin-2-yl-1H-benzimidazole

Procedure

The entitled compound was obtained in the same method as in Example 438 (step 2) or in accordance with the method or by combining it with an ordinary method but using 4-hydroxy-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyrazin-2-yl-1H-benzimidazole obtained in Example 442 and 2,4-difluoro-benzonitrile.

Workup

  1. customThe entitled compound was obtained in the same method as in Example 438 (step 2) or in accordance with the method

Sources & evidence

ORD record
ord-66a93e76712942c3813a3be8630cacbb
Source dataset
uspto-grants-2010_06
Patent number
US07728025B2

Linked notes

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