3-(4-Chlorophenyl)propyl methanesulfonate → HCID 22562250, compound

HRID 1348802

Reaction equation

HRID 1348802 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[C:12]([C:17]([O:19]C)=[O:18])[C:13](=[O:16])[NH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].CS(O[CH2:26][CH2:27][CH2:28][C:29]1[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=1)(=O)=O>>[C:17]([C:12]1[C:13](=[O:16])[N:14]([CH2:26][CH2:27][CH2:28][C:29]2[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=2)[N:15]=[C:10]([C:4]2[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([F:1])[CH:3]=2)[CH:11]=1)([OH:19])=[O:18]

Participants

3

Reactant 2

HCID 130797053-(4-Chlorophenyl)propyl methanesulfonateHCID 219914326-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

Product 1

HCID 22562250HCID 22562250, compoundYield 56.1%

Procedure

Following the procedure of Example 1(6), 6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one and 3-(4-chlorophenyl)-1-propanol methanesulfonate were reacted to yield a crude product. Without purification, the crude product was reacted further in accordance with the procedure of Example 1 (7) to yield the title compound as a pale yellow solid (yield: 56.1%).

Workup

  1. customwere reacted
  2. customto yield a crude product
  3. customWithout purification
  4. customthe crude product was reacted further in accordance with the procedure of Example 1 (7)

Sources & evidence

ORD record
ord-8946fe2f344c4a5fade9f1f716c65e78
Source dataset
uspto-grants-2007_05
Patent number
US07211577B2

Linked notes

Loading…