5-(2-Chloro-4-nitrophenyl)-1,3,4-thiadiazole-2-sulfonyl chloride → HCID 21092768, compound
Reaction equation
Cl.Cl.[CH2:3]([O:5][C:6](=[O:12])[CH2:7][NH:8][CH2:9][CH2:10][NH2:11])[CH3:4].[Cl:13][C:14]1[CH:19]=[C:18]([N+:20]([O-:22])=[O:21])[CH:17]=[CH:16][C:15]=1[C:23]1[S:27][C:26]([S:28](Cl)(=[O:30])=[O:29])=[N:25][N:24]=1>>[CH2:3]([O:5][C:6](=[O:12])[CH2:7][NH:8][CH2:9][CH2:10][NH:11][S:28]([C:26]1[S:27][C:23]([C:15]2[CH:16]=[CH:17][C:18]([N+:20]([O-:22])=[O:21])=[CH:19][C:14]=2[Cl:13])=[N:24][N:25]=1)(=[O:30])=[O:29])[CH3:4]Participants
3
Procedure
The title compound was synthesized by the reaction of N-(2-aminoethyl)-glycine ethyl ester 2HCl with 5-(2-chloro-4-nitrophenyl)-1,3,4-thiadiazole-2-sulfonyl chloride as per the procedure of example 1. 1H NMR (500 MHz; DMSO-d6) δ 8.60 (d, 1H), 8.54 (d, 1H), 8.40 (dd, 1H) 4.05 (q, 2H), 3.27 (s, 2H), 3.19 (t, 2H), 2.67 (t, 2H), 1.16 (t, 3H).
Sources & evidence
- ORD record
- ord-867b7ad33d414f3ab6d2d6192239f1a0
- Source dataset
- uspto-grants-2007_05