HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 135Generated: October 23, 2026
Iodobenzene → N-(2-(Dimethylamino)ethyl)aniline
https://huagongshe.com/en/reaction/135
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodobenzene | HCID 11575 | — |
| Reactant | N,N-Dimethylethylenediamine | HCID 66053 | — |
| Reagent | Cesium carbonate | HCID 10796 | — |
| Catalyst | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(2-(Dimethylamino)ethyl)aniline | HCID 81206 | 0% |
Reaction Steps
In a 50 mL round-bottomed flask (t=g) was unsym-Dimethylethylenediamine (1.080 mL, 9.80 mmol), Iodobenzene (0.549 mL, 4.90 mmol), and TRIS(DIBENZYLIDENEACETONE)DIPALLADIUM(0) (0.449 g, 0.49 mmol)Cesium carbonate (2.396 g, 7.35 mmol) andCesium carbonate (2.396 g, 7.35 mmol) were added. in DMF (10 mL) ([VOLUME]) to give a brown suspension. Reaction stirred over night at 100°C. no reaction.
Provenance & Evidence
| Source dataset | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-6eea29be7d4b47c5893b1e243ef41836 |
|---|
| Source note | 750 AstraZeneca ELN dataset |
|---|
