5-Ethynyl-2-methylpyridine → 4-(5-Ethynyl-pyridin-2-ylmethyl)-morpholine

Reaction equation

Br[C:2]1[CH:3]=[CH:4][C:5]([CH2:8][N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[N:6][CH:7]=1.[CH3:15][C:16]1C=CC(C#C)=CN=1>>[C:15]([C:2]1[CH:3]=[CH:4][C:5]([CH2:8][N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[N:6][CH:7]=1)#[CH:16]

Participants

Reactant 2

HCID 6381975-Ethynyl-2-methylpyridine

HCID 120852844-((5-Bromopyridin-2-yl)methyl)morpholine

Product 1

HCID 210973194-(5-Ethynyl-pyridin-2-ylmethyl)-morpholine

Procedure

4-(5-Ethynyl-pyridin-2-ylmethyl)-morpholine was prepared from 4-(5-bromo-pyridine-2-ylmethyl)-morpholine (U.S. Pat. No. 6,358,945) in the same manner as 2-methyl-5-ethynyl pyridine (Example 7).

Sources & evidence

ORD record: ord-7d13b816959647bcbb59f54d1db6afdb
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07214802B2

Reaction notes

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