Ethyl 3-oxovalerate → 5-Ethyl-1-isopropyl-1H-pyrazole-4-carbaldehyde

HRID 1350738Notes

Reaction equation

HRID 1350738 reaction equation
O=C(CC)CC(OCC)=O.Cl.C(NN)(C)C.[CH:17]1([C:20]2[N:24]([CH:25]([CH3:27])[CH3:26])[N:23]=[CH:22][C:21]=2[CH:28]=[O:29])C[CH2:18]1>>[CH2:17]([C:20]1[N:24]([CH:25]([CH3:26])[CH3:27])[N:23]=[CH:22][C:21]=1[CH:28]=[O:29])[CH3:18]

Participants

4

Reactant 3

HCID 78656Ethyl 3-oxovalerateHCID 855731-Isopropylhydrazine hydrochlorideHCID 196201355-cyclopropyl-1-(propan-2-yl)-1H-pyrazole-4-carbaldehyde

Product 1

HCID 210973415-Ethyl-1-isopropyl-1H-pyrazole-4-carbaldehyde

Procedure

5-Ethyl-1-isopropyl-1H-pyrazole-4-carbaldehyde was prepared with ethyl 3-oxopentanoate and isopropyl hydrazine hydrochloride in the same manner as 5-cyclopropyl-1-isopropyl-1H-pyrazole-4-carbaldehyde (Example 49).

Sources & evidence

ORD record
ord-b5ac44e945ab455999229901f06095e0
Source dataset
uspto-grants-2007_05
Patent number
US07214802B2

Reaction notes

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