Methanol → 3-Chloro-5-hydroxy-N-isopropyl-N-[2-(1-methyl-1H-tetrazol-5-yl)-ethyl]-benzamide

Reaction equation

[B:24]([Br:25])([Br:26])[Br:27].[CH3:28][OH:29].[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[N:7]([CH2:8][CH2:9][c:10]2[n:11][n:12][n:13][n:14]2[CH3:15])[CH:16]([CH3:17])[CH3:18])[cH:19][c:20]([O:22][CH3:23])[cH:21]1.[Cl:30][CH2:31][Cl:32]>>[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[N:7]([CH2:8][CH2:9][c:10]2[n:11][n:12][n:13][n:14]2[CH3:15])[CH:16]([CH3:17])[CH3:18])[cH:19][c:20]([OH:22])[cH:21]1

Participants

Reactant 4

HCID 887Methanol

HCID 6344Dichloromethane

HCID 25134Boron tribromide

HCID 183489363-Chloro-N-isopropyl-5-methoxy-N-[2-(1-methyl-1H-tetrazol-5-yl)ethyl]-benzamide

Product 1

HCID 183488353-Chloro-5-hydroxy-N-isopropyl-N-[2-(1-methyl-1H-tetrazol-5-yl)-ethyl]-benzamide

Sources & evidence

ORD record: ord-8b8dccfbbf784ba2a6a5def62ce83847
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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