Ethyl 2-(4-bromophenyl)-2-methylpropanoate → 2-Methyl-2-(1,3-thiazol-2-yl)propanoic acid

Reaction equation

[CH3:1][C:2]([C:9]1[S:10][CH:11]=[CH:12][N:13]=1)([CH3:8])[C:3]([O:5]CC)=[O:4].BrC1C=CC(C(C)(C)C(OCC)=O)=CC=1>>[CH3:8][C:2]([C:9]1[S:10][CH:11]=[CH:12][N:13]=1)([CH3:1])[C:3]([OH:5])=[O:4]

Participants

Reactant 2

HCID 11277257Ethyl 2-(4-bromophenyl)-2-methylpropanoate

HCID 21099803Ethyl 2-methyl-2-(thiazol-2-yl)propanoate

Product 1

HCID 210997222-Methyl-2-(1,3-thiazol-2-yl)propanoic acid

Procedure

The title compound was prepared according to the method of Example 22B substituting the product of Example 44D for the product of Example 22A.

Sources & evidence

ORD record: ord-eb42f3d3eedf46038aa0bd2c793ab33d
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07217838B2

Reaction notes

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