3,5-Difluoro-2-hydrazinylpyridine → 3,5-Difluoropyridin-2-amine

Charged in a hydrogenation reactor were 500 ml of methanol, 14.5 g of the compound obtained in Step 4 and 11.5 g of Raney nickel as a catalyst, and H2 gas was introduced therein. The reactor was kept at room temperature for 24 hours, and the reaction mixture was filtered through Cellite® to remove the catalyst. The resulting solution was concentrated under a reduced pressure to obtain 10.8 g of the title compound as a light yellow solid (purity: 98.0%).

1. additionCharged in a hydrogenation reactor
2. additionH2 gas was introduced
3. filtrationthe reaction mixture was filtered through Cellite®
4. customto remove the catalyst
5. concentrationThe resulting solution was concentrated under a reduced pressure

ORD record

ord-057a7ed5a273436abe021be72a2fd6d6

Source dataset

uspto-grants-2007_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07220863B2