2-(Benzenesulfonyl)-3-phenyloxaziridine → 2-(Methylsulfinyl)pyrimidine

HRID 1355683

Reaction equation

HRID 1355683 reaction equation
[CH3:1][S:2][C:3]1[N:8]=[CH:7][CH:6]=[CH:5][N:4]=1.C1(C2[O:17]N2S(C2C=CC=CC=2)(=O)=O)C=CC=CC=1>ClCCl>[CH3:1][S:2]([C:3]1[N:8]=[CH:7][CH:6]=[CH:5][N:4]=1)=[O:17]

Participants

4

Reactant 2

HCID 3204052-(Benzenesulfonyl)-3-phenyloxaziridineHCID 5227722-(Methylsulfanyl)pyrimidine

Product 1

HCID 114008322-(Methylsulfinyl)pyrimidine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The methylsulfanyl-pyrimidine compound of formula (83) is reacted with an oxidising agent, preferably 3-phenyl-2-(phenylsulfonyl)oxaziridine, in an organic solvent, preferably dichloromethane, at room temperature. The product of formula (84), a methanesulfinyl-pyrimidine derivative, is isolated by conventional means, and preferably reacted in the next step without further purification. The product of formula (84) may, however, be additionally purified by means of chromatography or recrystallisation.

Sources & evidence

ORD record
ord-224b15c6ee9741c48c8a184c2ab8484f
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Linked notes

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