Ethylamine → 2-Amino-4-ethylamino-6-furan-2-yl-pyrimidine-5-carbonitrile

HRID 1355761Notes

Reaction equation

HRID 1355761 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4](S(C)(=O)=O)[N:3]=1.[CH2:19]([NH2:21])[CH3:20]>COCCOC>[NH2:1][C:2]1[N:3]=[C:4]([NH:21][CH2:19][CH3:20])[C:5]([C:13]#[N:14])=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[N:7]=1

Participants

4

Reactant 2

HCID 6341EthylamineHCID 185073992-Amino-4-furan-2-yl-6-methanesulfonyl-pyrimidine-5-carbonitrile

Product 1

HCID 185076502-Amino-4-ethylamino-6-furan-2-yl-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-furan-2-yl-6-methanesulfonyl-pyrimidine-5-carbonitrile and ethylamine in DME. EI-MS m/e (%): 229 (M+, 100), 228 ([M—H]+, 76), 214 ([M—CH3]+, 84), 201 (50), 44 (61).

Sources & evidence

ORD record
ord-6a7e5e91952d4e7090615da10e0144ab
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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