2-amino-4-furan-2-yl-6-methanesulfonyl-pyrimidine-5-carbonitrile N-methylpiperazine → 2-Amino-4-furan-2-yl-6-(4-methyl-piperazin-1-yl)-pyrimidine-5-carbonitrile
Reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[NH2:8][C:9]1[N:14]=[C:13]([C:15]2[O:16][CH:17]=[CH:18][CH:19]=2)[C:12]([C:20]#[N:21])=[C:11](S(C)(=O)=O)[N:10]=1>COCCOC>[NH2:8][C:9]1[N:14]=[C:13]([C:15]2[O:16][CH:17]=[CH:18][CH:19]=2)[C:12]([C:20]#[N:21])=[C:11]([N:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)[N:10]=1Participants
3
Procedure
From 2-amino-4-furan-2-yl-6-methanesulfonyl-pyrimidine-5-carbonitrile N-methylpiperazine in DME. ES-MS m/e (%): 2859 (M+H+, 100), 228 (35).
Sources & evidence
- ORD record
- ord-189090cbe6184ff09434e251fc7559e2
- Source dataset
- uspto-grants-2003_07
- Patent number
- US06586441B2
Reaction notes
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