Acetone → Phthalazin-1-ylhydrazine;propan-2-ylidenehydrazine

HRID 13564

Reaction equation

HRID 13564 reaction equation
Cl.[NH:2]([C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[N:6][N:5]=1)[NH2:3].[CH3:14]C(C)=O>>[CH3:14][C:7](=[N:6][NH2:5])[CH3:8].[NH:2]([C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[N:6][N:5]=1)[NH2:3]

Participants

3

Reactant 2

HCID 180AcetoneHCID 9351Hydralazine Hydrochloride

Product 1

HCID 86590016Phthalazin-1-ylhydrazine;propan-2-ylidenehydrazine

Procedure

1-hydrazinophthalazine HCL (395 mg; 2 mmoles) is dissolved in 2.5 ml of acetone and allowed to react for 1 hour. The solvent is evaporated and the slightly yellow material is dried in vacuo to yield 411 mg of 1-hydrazinophthalazine acetone hydrazone. (99% of theoretical yield). [British Journal of Pharmacology 61: 345-349 (1977)]

Workup

  1. customto react for 1 hour
  2. customThe solvent is evaporated
  3. customthe slightly yellow material is dried in vacuo

Sources & evidence

ORD record
ord-fa33aa04990b413da75cdd22ca1aab4e
Source dataset
uspto-grants-2010_06
Patent number
US07728133B2

Linked notes

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