Thionyl Chloride → 2-(chloromethyl)-1,3-dimethoxyBenzene

HRID 1357029Notes

Reaction equation

HRID 1357029 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:4]=1[CH2:5]O.S(Cl)([Cl:15])=O>C1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:4]=1[CH2:5][Cl:15]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 2776839(2,6-Dimethoxyphenyl)methanol

Product 1

HCID 127070022-(chloromethyl)-1,3-dimethoxyBenzene

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

0.43 g (2.56 mmol) of 2,6-dimethoxybenzyl alcohol was dissolved in 5 ml of benzene, and the resultant solution was added with 0.40 g (3.36 mmol) of thionyl chloride at a room temperature. The mixture was then stirred for an hour at a room temperature to facilitate the provided compounds to react. The reacted solution was then condensed under reduced pressure to obtain a crude product of 2,6-dimethoxybenzyl chloride.

Workup

  1. customto react
  2. customcondensed under reduced pressure

Sources & evidence

ORD record
ord-76f7ae5875dc448b82673af386701706
Source dataset
uspto-grants-2003_07
Patent number
US06589967B1

Reaction notes

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