Thionyl Chloride → 2-(chloromethyl)-1,3-dimethoxyBenzene

HRID 1357031Notes

Reaction equation

HRID 1357031 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:4]=1[CH2:5]O.S(Cl)([Cl:15])=O>C1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:4]=1[CH2:5][Cl:15]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 2776839(2,6-Dimethoxyphenyl)methanol

Product 1

HCID 127070022-(chloromethyl)-1,3-dimethoxyBenzene

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

0.49 g (2.93 mmol) of 2,6-dimethoxybenzyl alcohol was dissolved in 6 ml of benzene, and the resultant solution was added with 0.41 g (3.32 mmol) of thionyl chloride at a room temperature. The thus obtained solution was then stirred for 1.5 hours at a room temperature to complete a reaction. The reacted solution was then condensed under reduced pressure to obtain a crude product of 2,6-dimethoxybenzyl chloride.

Workup

  1. customa reaction
  2. customcondensed under reduced pressure

Sources & evidence

ORD record
ord-18eef18fd527480fadf8042441fb3020
Source dataset
uspto-grants-2003_07
Patent number
US06589967B1

Reaction notes

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