2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → Asarone

Participants

Reaction Steps

Preparation of α-asarone via dehydrogenation of 2,4,5-trimethoxyphenylpropane with DDQ containing little amount of silica gel: Addition of a catalytic amount of silica gel (0.2-0.6 g) drastically accelerated the rate of reaction as well as improved the yield of α-asarone when above dehydrogenation process (Example II-a) was conducted under the same condition resulting α-asarone in 72% yield and trans-2,4,5-trimethoxycinnamaldehyde in 18% yield.

Provenance & Evidence