2,1,3-Benzothiadiazol-5-ylmethanol → 2,1,3-Benzothiadiazole-5-carbaldehyde

HRID 1357750

Reaction equation

HRID 1357750 reaction equation
[OH:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]2=[N:7][S:8][N:9]=[C:5]2[CH:4]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[N:7]1[S:8][N:9]=[C:5]2[CH:4]=[C:3]([CH:2]=[O:1])[CH:11]=[CH:10][C:6]=12

Participants

4

Reactant 1

HCID 27762942,1,3-Benzothiadiazol-5-ylmethanol

Product 1

HCID 27762902,1,3-Benzothiadiazole-5-carbaldehydeYield 72.3%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

5-Hydroxymethylbenzo-2, 1,3-thiadiazole (2.6 g, 16 mmol) and manganese dioxide (6.0 g, 64 mmol) in chloroform (150 mL) were stirred at room temperature overnight. The reaction mixture was filtered off and the filtrate was evaporated to provide 1.9 g of the title compound.

Workup

  1. filtrationThe reaction mixture was filtered off
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-d6214540b07f41f691e40f83b9cf0f40
Source dataset
uspto-grants-2003_07
Patent number
US06593335B1

Linked notes

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