2,1,3-Benzothiadiazol-5-ylmethanol → 2,1,3-Benzothiadiazole-5-carbaldehyde
Reaction equation
[OH:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]2=[N:7][S:8][N:9]=[C:5]2[CH:4]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[N:7]1[S:8][N:9]=[C:5]2[CH:4]=[C:3]([CH:2]=[O:1])[CH:11]=[CH:10][C:6]=12Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
5-Hydroxymethylbenzo-2, 1,3-thiadiazole (2.6 g, 16 mmol) and manganese dioxide (6.0 g, 64 mmol) in chloroform (150 mL) were stirred at room temperature overnight. The reaction mixture was filtered off and the filtrate was evaporated to provide 1.9 g of the title compound.
Workup
- filtrationThe reaction mixture was filtered off
- customthe filtrate was evaporated
Sources & evidence
- ORD record
- ord-d6214540b07f41f691e40f83b9cf0f40
- Source dataset
- uspto-grants-2003_07
- Patent number
- US06593335B1
Reaction notes
Loading…