5-(Trifluoromethyl)-1,3,4-oxadiazol-2-amine → 9H-Xanthene-9carboxylic acid (5-trifluoromethyl-[1,3,4]oxadiazol-2-yl)-amide

HRID 1358441

Reaction equation

HRID 1358441 reaction equation
CC1C=C(C)N([C:8]([CH:10]2[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[O:17][C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)=[O:9])N=1.[F:24][C:25]([F:33])([F:32])[C:26]1[O:30][C:29]([NH2:31])=[N:28][N:27]=1>>[F:24][C:25]([F:33])([F:32])[C:26]1[O:30][C:29]([NH:31][C:8]([CH:10]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[O:17][C:18]3[C:23]2=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:9])=[N:28][N:27]=1

Participants

3

Reactant 2

HCID 5226305-(Trifluoromethyl)-1,3,4-oxadiazol-2-amineHCID 4521579(3,5-dimethylpyrazol-1-yl)-(9H-xanthen-9-yl)methanone

Product 1

HCID 539558839H-Xanthene-9carboxylic acid (5-trifluoromethyl-[1,3,4]oxadiazol-2-yl)-amide

Procedure

The title compound, white solid, m.p. 220-223° C.(decomp.), and MS: m/e=362.2 (M+H+) was prepared in accordance with the general method of example 48a from (3,5-dimethylpyrazol-1-yl)-(9H-xanthen-9-yl)-methanone and 5-trifluoromethyl-[1,3,4]oxadiazol-2-ylamine [U.S. Pat. No. 2,883,391].

Sources & evidence

ORD record
ord-74be9b5933b64962bfb4aad2778fc0d8
Source dataset
uspto-grants-2003_07
Patent number
US06596743B2

Linked notes

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