5-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chloride → HCID 18180138, compound
Reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[C:16]([NH2:22])[CH:17]=[CH:18][C:19]=2[O:20][CH3:21])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6]C=CC=1.[Cl:23][C:24]1[CH:25]=[CH:26][C:27]2[S:31][C:30]([S:32](Cl)(=[O:34])=[O:33])=[C:29]([CH3:36])[C:28]=2[CH:37]=1>CC(C)=O>[CH:2]1([CH2:1][N:8]2[CH2:9][CH2:10][N:11]([C:14]3[CH:15]=[C:16]([NH:22][S:32]([C:30]4[S:31][C:27]5[CH:26]=[CH:25][C:24]([Cl:23])=[CH:37][C:28]=5[C:29]=4[CH3:36])(=[O:34])=[O:33])[CH:17]=[CH:18][C:19]=3[O:20][CH3:21])[CH2:12][CH2:13]2)[CH2:7][CH2:6]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 3-(4-benzyl-piperazin-1-yl)-4-methoxy-phenylamine (D22) (1 mmol) in acetone (5 ml) was added 5-chloro-3-methylbenzothiophene-2-sulphonyl chloride (1 mmol). Stirring was continued at room temperature for 14 hrs. The hydrochloride salt of the sulphonamide was collected by filtration, triturated with diethyl ether and dried in vacuo in 42% yield. Found MH+ 506/508.