Acetic Anhydride → HCID 18180200, compound
Reaction equation
[NH2:1][C:2]1[C:7]([Br:8])=[N:6][CH:5]=[C:4]([NH2:9])[N:3]=1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>COC(OC)C>[NH2:1][C:2]1[C:7]([Br:8])=[N:6][CH:5]=[C:4]([NH:9][C:10](=[O:12])[CH3:11])[N:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 2,6-diamino-3-bromopyrazine (10.509, 0.056 mole) in dry 1,1-dimethoxyethane (168 ml) and acetic anhydride (7.91 ml, 8.56 g, 0.084 mole) was refluxed under nitrogen for 2.50 hrs. The cooled mixture was evaporated in vacuo. The residue was triturated with ether, filtered and dried in vacuo Yield 10.31 g (80%), M.p. 218-221° C.
Workup
- temperaturewas refluxed under nitrogen for 2.50 hrs
- customThe cooled mixture was evaporated in vacuo
- customThe residue was triturated with ether
- filtrationfiltered
- customdried in vacuo Yield 10.31 g (80%), M.p. 218-221° C.
Sources & evidence
- ORD record
- ord-9d224b91d28b498e86c65bdbe264a534
- Source dataset
- uspto-grants-2003_07
- Patent number
- US06599905B2
Reaction notes
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