Methanol → HCID 18182209, compound
Reaction equation
Cl[C:2]1[C:7]([C:8]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:15][OH:16].C[O-].[Na+]>O>[CH3:15][O:16][C:2]1[C:7]([C:8]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 1.64 g of 2-chloro-3-(2-thienylcarbonyl)pyridine, 4.5 ml of a methanol solution of 28% sodium methoxide and 2.0 ml of methanol was heated under stirring for 30 minutes. After cooling as it was, water was added to the reaction solution and the mixture was extracted with ethyl acetate. The organic phase was washed with brine and the solvent was removed, to give 1.46 g of the target compound.
Workup
- temperaturewas heated
- temperatureAfter cooling as it
- extractionthe mixture was extracted with ethyl acetate
- washThe organic phase was washed with brine
- customthe solvent was removed
Sources & evidence
- ORD record
- ord-af2b9092f05f4d2892503c49254bcc4f
- Source dataset
- uspto-grants-2003_07
- Patent number
- US06599917B1
Reaction notes
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