HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 136Generated: October 23, 2026
3-Aminoazetidine, 3-BOC protected → tert-butyl N-[1-(2-methoxy-4-pyridinyl)azetidin-3-yl]carbamate
https://huagongshe.com/en/reaction/136
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Aminoazetidine, 3-BOC protected | HCID 1519405 | — |
| Reactant | 4-Bromo-2-methoxypyridine | HCID 14062309 | — |
| Reagent | Sodium t-butoxide | HCID 23676156 | — |
| Catalyst | Binap, (A+-)- | HCID 634876 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | tert-butyl N-[1-(2-methoxy-4-pyridinyl)azetidin-3-yl]carbamate | HCID 118055029 | 100.28% |
Reaction Steps
A mixture of all the reactants in toluene was heated in a sealed vial at 70 °C overnight. According to LC-MS the reaction was completed and the product had been formed. Toluene was removed, water was added and the product was extracted with DCM. The organic phase was dried through phase separator and concentrated. The crude was used without further purification in the next step, EN01762-02.
Provenance & Evidence
| Source dataset | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-3870c5bc1f6548e38bd05a0e29b91f59 |
|---|
| Source note | 750 AstraZeneca ELN dataset |
|---|
