Ethyl 2-(2-aminothiazol-5-ylthio)acetate → HCID 57776316, compound

Reaction equation

[F:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][C:7]2[CH:8]=[C:9]([CH:13]=[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])[CH:15]=2)[C:10]([OH:12])=O)=[CH:4][CH:3]=1.[CH2:23]([O:25][C:26](=[O:35])[CH2:27][S:28][C:29]1[S:33][C:32]([NH2:34])=[N:31][CH:30]=1)[CH3:24]>>[CH2:23]([O:25][C:26](=[O:35])[CH2:27][S:28][C:29]1[S:33][C:32]([NH:34][C:10](=[O:12])[C:9]2[CH:13]=[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])[CH:15]=[C:7]([O:6][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:22][CH:21]=3)[CH:8]=2)=[N:31][CH:30]=1)[CH3:24]

Participants

Reactant 2

HCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetate

HCID 66970051HCID 66970051, compound

Product 1

HCID 57776316HCID 57776316, compound

Procedure

The title compound was prepared from 3-(4-fluoro-phenoxy)-5-isobutoxy-benzoic acid and (2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester following general procedure A

Sources & evidence

ORD record: ord-c62d3cb091f840939c1829697161f34b
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07880012B2

Reaction notes

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