Ethyl indole-2-carboxylate → 7-Fluoro-1-methylindole-3-carboxaldehyde

HRID 1361979

Reaction equation

HRID 1361979 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[C:7]2[CH:11]=[O:12].N1C2C(=CC=CC=2)C=[C:14]1C(OCC)=O>>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH3:14])[CH:8]=[C:7]2[CH:11]=[O:12]

Participants

3

Reactant 2

HCID 73125Ethyl indole-2-carboxylateHCID 221391207-Fluoro-1H-indole-3-carbaldehyde

Product 1

HCID 221390377-Fluoro-1-methylindole-3-carboxaldehydeYield 43%

Procedure

According to the procedure of Preparation 9 (a), except substituting 7-fluoro-1H-indole-3-carboxaldehyde (0.5 g, 3.1 mmole) for the ethyl indole-2-carboxylate, the title compound (0.23 g, 43%) was prepared as a viscous oil: MS (ES) m/e 178 (M+H)+.

Sources & evidence

ORD record
ord-27a67b25279a4b50818e182649272ed9
Source dataset
uspto-grants-2011_02
Patent number
US07879872B2

Linked notes

Loading…