HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-dimethyl-1H-indole-2-carbaldehyde → 4-fluoro-1-methyl-3-(methylaminomethyl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-dimethyl-1H-indole-2-carbaldehyde | HCID 2771468 | — |
| Reactant | 4-fluoro-1-methyl-1H-indole-3-carbaldehyde | HCID 22138994 | — |
| Reactant | Methyl 2-((5-bromopyridin-2-yl)amino)acetate | HCID 22139049 | — |
| Product | 4-fluoro-1-methyl-3-(methylaminomethyl)-1H-indole | HCID 22139151 | 77% |
Reaction Steps
According to the procedure of Preparation 11 (c), except substituting 4-fluoro-1-methyl-1H-indole-3-carboxaldehyde (0.3 g, 1.69 mmole) for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (0.2 g, 77%) was prepared as a viscous oil: MS (ES) m/e 193 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07879872B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-77306dd59f2b43fb918e6aa3a81063ba |
| Source note | uspto-grants-2011_02 |