Phosphorus pentachloride → HCID 178506325, compound
Reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH:8][C:9](=O)[C:10]([F:13])([F:12])[F:11])=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:16]>ClC(Cl)C>[Cl:1][C:2]1[N:7]=[N:6][C:5](/[N:8]=[C:9](\[Cl:16])/[C:10]([F:13])([F:12])[F:11])=[CH:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 3.8 g (17 mmol) of the crude product of Step A and 4.2 g (22 mmol) of phosphorous pentachloride in 200 mL of dichloroethane was heated at reflux temperature under nitrogen. After 6 h the reaction was cooled to ambient temperature then concentrated in vacuo to yield a crude oil which was carried on to Step C.
Workup
- temperatureat reflux temperature under nitrogen
- concentrationthen concentrated in vacuo
- customto yield a crude oil which
Sources & evidence
- ORD record
- ord-5e31c15ba87147b68d8838290b414a37
- Source dataset
- uspto-grants-2011_02
- Patent number
- US07884104B2
Reaction notes
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