Ethyl 3-chloro-4H-thieno[3,2-B]pyrrole-5-carboxylate → HCID 59648579, compound
Reaction equation
Br[C:2]1[C:6]2[NH:7][C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:9][C:5]=2[O:4][CH:3]=1.[Cl:15]C1C2NC(C(OCC)=O)=CC=2SC=1>CCCCCCC.CCOC(C)=O>[Cl:15][C:2]1[C:6]2[NH:7][C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:9][C:5]=2[O:4][CH:3]=1Participants
4
Procedure
The title compound was synthesized from ethyl 3-bromo-4H-furo[3,2-b]pyrrole-5-carboxylate (200 mg, 0.774 mmol) using the conditions to synthesize ethyl 3-chloro-4H-thieno[3,2-b]pyrrole-5-carboxylate. Chromatography (silica gel, heptane/EtOAc) yielded ethyl 3-chloro-4H-furo[3,2-b]pyrrole-5-carboxylate (70 mg, 42% yield).
Sources & evidence
- ORD record
- ord-4b159802e4c2467d91b226eb472f5f8f
- Source dataset
- uspto-grants-2011_02
- Patent number
- US07884124B2
Reaction notes
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