2-Methoxyphenyl chloroformate → 2-Methoxyphenyl 4-(prop-2-ynyl)piperidine-1-carboxylate

HRID 1363967

Reaction equation

HRID 1363967 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH3:12])=[O:3].[CH2:13]([CH:16]1[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]1)[C:14]#[CH:15]>>[CH2:13]([CH:16]1[CH2:21][CH2:20][N:19]([C:2]([O:4][C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[O:11][CH3:12])=[O:3])[CH2:18][CH2:17]1)[C:14]#[CH:15]

Participants

3

Reactant 2

HCID 33621432-Methoxyphenyl chloroformateHCID 18187546Tert-butyl 4-(prop-2-yn-1-yl)piperidine-1-carboxylate

Product 1

HCID 578388762-Methoxyphenyl 4-(prop-2-ynyl)piperidine-1-carboxylate

Procedure

2-(methoxy)phenyl chloroformate (5.00 g, 26.8 mmol) was added to a solution of tert-butyl 4-(prop-2-ynyl)piperidine-1-carboxylate (4.60 g, 20.6 mmol) according to general procedure 1. Yield=5.03 g, 89%. m/z MH+=274.04. HPLC rt=8.7 min.

Workup

  1. customHPLC rt=8.7 min.

Sources & evidence

ORD record
ord-95167c31902948bda7775232eb67c910
Source dataset
uspto-grants-2011_02
Patent number
US07888329B2

Linked notes

Loading…