HCID 63900315, compound → 2-Morpholin-4-ylsulfonylacetic acid
Reaction equation
C[O:2][C:3](=[O:14])[CH2:4][S:5]([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)(=[O:7])=[O:6]>C1CCCCC1.C(OCC)(=O)C>[N:8]1([S:5]([CH2:4][C:3]([OH:14])=[O:2])(=[O:7])=[O:6])[CH2:9][CH2:10][O:11][CH2:12][CH2:13]1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
(Morpholine-4-sulfonyl)acetic acid methyl ester (0.5 g, 2.24 mmol) is dissolved in 0.66 N KOH aqueous ethanol solution (1/1, 150 mL) and the mixture is heated at reflux during 16 h. The solvent is evaporated and residue is extracted with dichloromethane/methanol 4:1 to yield the title compound.
Workup
- temperaturethe mixture is heated
- temperatureat reflux during 16 h
- customThe solvent is evaporated
- extractionresidue is extracted with dichloromethane/methanol 4:1
Sources & evidence
- ORD record
- ord-117390f3f3914bee9b79964ddae75a0b
- Source dataset
- uspto-grants-2011_02
- Patent number
- US07888351B2
Reaction notes
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