Water → N-(4-Amino-6-bromo-5-cyano-pyridin-2-yl)-acetamide
Reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([Br:10])[N:5]=[C:4]([NH2:11])[CH:3]=1.[C:12](Cl)([CH3:14])=[O:13].O>N1C=CC=CC=1>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([Br:10])[N:5]=[C:4]([NH:11][C:12](=[O:13])[CH3:14])[CH:3]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
4,6-Diamino-2-bromo-nicotinonitrile (100 mg, 0.47 mmol) was dissolved in 1.0 mL of anhydrous pyridine. AcCl (225 μL, 2.35 mmol) was dropped in slowly. The resulting mixture was shaken overnight at ambient temperature. Water (5 mL) was added to the mixture mixture. The resulting brown solid was collected through filtration, washed with cold water, and dried in a vacuum oven to provide the title compound (100 mg, 83%).
Workup
- filtrationThe resulting brown solid was collected through filtration
- washwashed with cold water
- customdried in a vacuum oven
Sources & evidence
- ORD record
- ord-26722478daf54c5cb5495e98b9091a83
- Source dataset
- uspto-grants-2011_02
- Patent number
- US07888374B2
Reaction notes
Loading…