Morpholine → HCID 59619436, compound

Reaction equation

[C:1]([C:3]1([NH:6][C:7]([CH:9]2[CH2:13][CH2:12][CH:11]([S:14]([C:17]3[CH:22]=[CH:21][C:20](F)=[CH:19][C:18]=3[Cl:24])(=[O:16])=[O:15])[CH2:10]2)=[O:8])[CH2:5][CH2:4]1)#[N:2].[NH:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1>>[C:1]([C:3]1([NH:6][C:7]([C@@H:9]2[CH2:13][CH2:12][C@@H:11]([S:14]([C:17]3[CH:22]=[CH:21][C:20]([N:25]4[CH2:30][CH2:29][O:28][CH2:27][CH2:26]4)=[CH:19][C:18]=3[Cl:24])(=[O:16])=[O:15])[CH2:10]2)=[O:8])[CH2:5][CH2:4]1)#[N:2]

Participants

Reactant 2

HCID 8083Morpholine

HCID 72340489HCID 72340489, compound

Product 1

HCID 59619436HCID 59619436, compound

Procedure

The title compound was synthesized in analogy to Example 80, from Rac-(1S,35)-3-(2-chloro-4-fluoro-benzenesulfonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide and morpholine to afford the desired product as a light yellow oil. MS (EI): 438.2 (M+H)+.

Sources & evidence

ORD record: ord-6b601bb95e5b4b0f8b1c04b9c0b8470f
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07893099B2

Reaction notes

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