4-Bromo-2-chlorobenzene-1-thiol → HCID 66918513, compound

HRID 1367571

Reaction equation

HRID 1367571 reaction equation
[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][C@H:9](OS(C)(=O)=O)[CH2:8][C@H:7]1[C:16]([N:18]1[CH2:22][CH2:21][C:20]([F:24])([F:23])[CH2:19]1)=[O:17])=[O:5])[CH3:2].[Cl:25][C:26]1[CH:31]=[C:30]([Br:32])[CH:29]=[CH:28][C:27]=1[SH:33]>>[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][C@@H:9]([S:33][C:27]2[CH:28]=[CH:29][C:30]([Br:32])=[CH:31][C:26]=2[Cl:25])[CH2:8][C@H:7]1[C:16]([N:18]1[CH2:22][CH2:21][C:20]([F:23])([F:24])[CH2:19]1)=[O:17])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 199152914-Bromo-2-chlorobenzene-1-thiolHCID 86649034HCID 86649034, compound

Product 1

HCID 66918513HCID 66918513, compound

Procedure

The title compound was prepared in analogy to example 68/69 step 8 using (1R,2R,4R)-2-(3,3-Difluoro-pyrrolidine-1-carbonyl)-4-methanesulfonyloxy-cyclopentanecarboxylic acid ethyl ester (example 186 step 3) and 2-chloro-4-bromothiophenol. Light yellow oil (89%). MS (EI): 498.0 (M+H)+.

Sources & evidence

ORD record
ord-8fc2e365dceb4938b149d0ecfd2c80df
Source dataset
uspto-grants-2011_02
Patent number
US07893099B2

Linked notes

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