HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 4-[2-[2-Ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Lithium Bromide | HCID 82050 | — |
| Reactant | 1-(2-Bromoethoxy)-4-nitrobenzene | HCID 235987 | — |
| Reactant | 2-Ethyl-6-methylpyrimidin-4(1h)-one | HCID 135417368 | — |
| Product | 4-[2-[2-Ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]nitrobenzene | HCID 21960135 | 30.9% |
Reaction Steps
The title compound (5.2 g, 25%) was prepared from 2-ethyl-4-methyl-1,6-dihydro-6-pyrimidone (7.65 g, 55.43 mmol), 4-[2-bromoethoxy]nitrobenzene (15.0 g, 60.97 mmol), LiBr (11.09 g, 127.49 mmol) and 60% NaH (2.76 g, 72.06 mmol) as base by a similar procedure to that described in preparation 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06573268B1 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-88be08653ddd4b0388f9768503e69086 |
| Source note | uspto-grants-2003_06 |