Water → 6-Bromo-3-nitro-2-pyridinamine
Reaction equation
Br[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Br:11])[N:3]=1.[NH4+:12].C(O)C.O>C(O)C>[NH2:12][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Br:11])[N:3]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a suspension of 2,6-dibromo-3-nitropyridine (5.00 g) in ethanol (10 ml) was added a solution (6.8 M, 15 ml) of ammonium/ethanol at room temperature, and the mixture was stirred at room temperature for 19 hr in a sealed container. Water (25 ml) was added to the reaction mixture, and the precipitate was collected by filtration and washed with ethanol. This was suspended in ethanol (55 ml), heated, and allowed to cool. The precipitate was collected by filtration to give 2-amino-6-bromo-3-nitropyridine as a yellow powder (3.19 g).
Workup
- filtrationthe precipitate was collected by filtration
- washwashed with ethanol
- temperatureheated
- temperatureto cool
- filtrationThe precipitate was collected by filtration
Sources & evidence
- ORD record
- ord-cf8c280b8dfd4666ad89c9c8484a8bcb
- Source dataset
- uspto-grants-2003_06
- Patent number
- US06573274B1
Reaction notes
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