3-Ethenylbenzonitrile → HCID 18752908, compound

HRID 1370591Notes

Reaction equation

HRID 1370591 reaction equation
Br[C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.[C:10]([C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=1)[CH:15]=[CH2:16])#[N:11]>C(Cl)Cl>[NH2:9][C:3]1[C:2](/[CH:16]=[CH:15]/[C:14]2[CH:13]=[C:12]([CH:19]=[CH:18][CH:17]=2)[C:10]#[N:11])=[CH:7][C:6]([Cl:8])=[CH:5][N:4]=1

Participants

4

Reactant 2

HCID 2205433-EthenylbenzonitrileHCID 27639713-Bromo-5-chloropyridin-2-amine

Product 1

HCID 18752908HCID 18752908, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from 3-bromo-5-chloro-2-pyridinamine and 3-cyanostyrene. Methylene chloride extracts of the crude reaction mixture were concentrated and the desired product purified by column chromatography on silica gel eluting with methylene chloride—methanol (98:2) to give a yellow solid:

Workup

  1. concentrationwere concentrated
  2. customthe desired product purified by column chromatography on silica gel eluting with methylene chloride—methanol (98:2)
  3. customto give a yellow solid

Sources & evidence

ORD record
ord-5288ea3323c94fdcb98ad9caf0210fb7
Source dataset
uspto-grants-2003_06
Patent number
US06583162B1

Reaction notes

Loading…