Dimethylsulphamoyl chloride → 7-Dimethylsulfamoyl-3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indole

HRID 13715

Reaction equation

[CH2:1]([C:3]1([C:13]2[C:21]3[C:16](=[C:17](N)[CH:18]=[CH:19][CH:20]=3)[NH:15][CH:14]=2)[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2].[CH3:23][N:24]([CH3:29])[S:25](Cl)(=[O:27])=[O:26]>>[CH3:23][N:24]([CH3:29])[S:25]([C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:16]=1[NH:15][CH:14]=[C:13]2[C:3]1([CH2:1][CH3:2])[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1)(=[O:27])=[O:26]

Participants

Reactant 2

HCID 83372Dimethylsulphamoyl chloride

HCID 589417073-(1-Ethyl-5-fluoro-indan-1-yl)-1H-indol-7-ylamine

Product 1

HCID 685854587-Dimethylsulfamoyl-3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indole

Procedure

Utilizing 3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-ylamine and dimethyl sulfamoyl chloride, the title compound is prepared as in example 15. 0.16 g (29%). LC-MS m/z 402.1 (M++1).

Sources & evidence

ORD record: ord-0630b0abd04f4f82a35413fda4e1b080
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07728150B2

Linked notes

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