Ammonia → HCID 20241990, compound
Reaction equation
[NH3:1].[ClH:2].[I:3][C:4]1[CH:5]=[C:6]([CH:12]=[CH:13][CH:14]=1)[C:7](=[NH:11])OCC>C(O)C>[ClH:2].[I:3][C:4]1[CH:5]=[C:6]([CH:12]=[CH:13][CH:14]=1)[C:7]([NH2:11])=[NH:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Ammonia gas was bubbled into an ice-cold suspension of the product (1.00 g, 3.21 mmol) from Step A in 20 mL of absolute ethanol for 20 min. The resultant clear solution was allowed to warm to room temperature and stirred for 48 h. The reaction mixture was then concentrated under reduced pressure, and the residue was triturated with diethyl ether. The supernatant was decanted, and the residual gummy product was dried in vacuo to afford the title compound as white foam.
Workup
- concentrationThe reaction mixture was then concentrated under reduced pressure
- customthe residue was triturated with diethyl ether
- customThe supernatant was decanted
- customthe residual gummy product was dried in vacuo
Sources & evidence
- ORD record
- ord-0db41156346b41e385a9917975453e08
- Source dataset
- uspto-grants-2007_01
- Patent number
- US07157490B2
Reaction notes
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