2,2,3,3,3-Pentafluoropropylamine → HCID 86596820, compound

Reaction equation

[CH3:1][O:2][C:3](=[O:10])[CH:4]([O:8][CH3:9])[C:5](O)=[O:6].[F:11][C:12]([F:19])([C:15]([F:18])([F:17])[F:16])[CH2:13][NH2:14]>>[CH3:1][O:2][C:3](=[O:10])[CH:4]([O:8][CH3:9])[C:5]([NH:14][CH2:13][C:12]([F:19])([F:11])[C:15]([F:18])([F:17])[F:16])=[O:6]

Participants

Reactant 2

HCID 790022,2,3,3,3-Pentafluoropropylamine

HCID 15004075113137-33-0

Product 1

HCID 86596820HCID 86596820, compound

Procedure

2-Methoxy-malonic acid monomethyl ester was coupled with 2,2,3,3,3-pentafluoro-propylamine in analogy to the description in Example 73 to yield 2-methoxy-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid methyl ester as colourless oil,

Sources & evidence

ORD record: ord-59e8e200e2c549a58e91fe8b4c6c2951
Source dataset: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07160875B2

Reaction notes

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