1-(2,3-Dihydro-1H-inden-4-yl)piperazine → 7-[4-(4-Indan-4-yl-piperazin-1-yl)-butoxy]-5-methyl-3,4-dihydro-1H-[1,8]naphthyridin-2-one

HRID 1373613Notes

Reaction equation

HRID 1373613 reaction equation
[CH3:1][C:2]1[C:11]2[CH2:10][CH2:9][C:8](=[O:12])[NH:7][C:6]=2[N:5]=[C:4]([O:13][CH2:14][CH2:15][CH2:16][CH:17]=O)[CH:3]=1.[CH2:19]1[C:27]2[C:22](=[C:23]([N:28]3[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]3)[CH:24]=[CH:25][CH:26]=2)[CH2:21][CH2:20]1>>[CH2:19]1[C:27]2[C:22](=[C:23]([N:28]3[CH2:29][CH2:30][N:31]([CH2:17][CH2:16][CH2:15][CH2:14][O:13][C:4]4[N:5]=[C:6]5[C:11]([CH2:10][CH2:9][C:8](=[O:12])[NH:7]5)=[C:2]([CH3:1])[CH:3]=4)[CH2:32][CH2:33]3)[CH:24]=[CH:25][CH:26]=2)[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 184748291-(2,3-Dihydro-1H-inden-4-yl)piperazineHCID 210733504-(4-Methyl-7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde

Product 1

HCID 210738017-[4-(4-Indan-4-yl-piperazin-1-yl)-butoxy]-5-methyl-3,4-dihydro-1H-[1,8]naphthyridin-2-one

Procedure

The title compound was prepared by reductive amination of 4-(4-methyl-7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde with 1-indan-4-yl-piperazine according to the above procedure. MS: APCI: M+1: 435.6 (Exact Mass: 434.27).

Sources & evidence

ORD record
ord-b10da82b75144b9fb21f69e619e38036
Source dataset
uspto-grants-2007_01
Patent number
US07160888B2

Reaction notes

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