t-Butyl 3-difluoromethyl-4-(4-methylpiperazin-1-ylmethyl)benzoate → HCID 23145928, compound
Reaction equation
[F:1][CH:2]([F:24])[C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][C:15]=1[CH2:16][N:17]1[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]1)[C:6]([O:8]C(C)(C)C)=[O:7]>CO>[F:24][CH:2]([F:1])[C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][C:15]=1[CH2:16][N:17]1[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH2:22]1)[C:6]([OH:8])=[O:7]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
This compound was prepared in the same manner as in Reference Example 1 (step 6), except that t-butyl 3-difluoromethyl-4-(4-methylpiperazin-1-ylmethyl)benzoate obtained in the step 5 was used, and that the resulting crude product was mixed with methanol, insolubles were removed by filtration, the filtrate was distilled off under reduced pressure, and then the residue was crystallized from acetonitrile.
Workup
- customobtained in the step 5
- customwere removed by filtration