Formamide → 4,5-Dianilinophthalimide
Reaction equation
[NH:1]([C:8]1[CH:9]=[C:10]2[C:15](=[O:16])[O:14][C:12](=O)[C:11]2=[CH:17][C:18]=1[NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.C([NH2:29])=O>>[NH:1]([C:8]1[CH:9]=[C:10]2[C:15](=[O:16])[NH:29][C:12](=[O:14])[C:11]2=[CH:17][C:18]=1[NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Participants
4
Procedure
A suspension of 21.9 g (66.3 mmol) of 4,5-bis(anilino)phthalic anhydride in 60 ml of formamide under argon atmosphere is heated at 125°-130° for 5 hours. The reaction mixture is cooled to 70°, and 250 ml of water are slowly added. This mixture is cooled to 0° for 30 minutes, and the reddish crystals are filtered off, washed with water and dried. Recrystallization from DMF/water yields the title compound in the form of orange crystals, m.p. 205°-207° C., FAB-MS: 330 [M+ +H].
Workup
- temperatureis heated at 125°-130° for 5 hours