Acetate → ethyl [(cis-3-{6-[(2'-cyanobiphenyl-4-yl)methyl]-5-oxo-7-propyl[1,2,4]triazolo[1,5-a]pyrimidin-4(5H)-yl}cyclobutyl)oxy]acetate

HRID 137747

Reaction equation

HRID 137747 reaction equation
[C:42]([O-:43])(=[O:44])[CH3:45].[CH3:47][c:48]1[cH:49][cH:50][cH:51][cH:52][cH:53]1.[N+:34](=[N-:35])=[CH:36][C:37](=[O:38])[O:39][CH2:40][CH3:41].[OH:1][CH:2]1[CH2:3][CH:4]([n:6]2[c:7]3[n:8]([c:9]([CH2:28][CH2:29][CH3:30])[c:10]([CH2:13][c:14]4[cH:15][cH:16][c:17](-[c:20]5[c:21]([C:26]#[N:27])[cH:22][cH:23][cH:24][cH:25]5)[cH:18][cH:19]4)[c:11]2=[O:12])[n:31][cH:32][n:33]3)[CH2:5]1.[Rh+:46]>>[O:1]([CH:2]1[CH2:3][CH:4]([n:6]2[c:7]3[n:8]([c:9]([CH2:28][CH2:29][CH3:30])[c:10]([CH2:13][c:14]4[cH:15][cH:16][c:17](-[c:20]5[c:21]([C:26]#[N:27])[cH:22][cH:23][cH:24][cH:25]5)[cH:18][cH:19]4)[c:11]2=[O:12])[n:31][cH:32][n:33]3)[CH2:5]1)[CH2:36][C:37](=[O:38])[O:39][CH2:40][CH3:41]

Participants

6

Reactant 5

HCID 175AcetateHCID 1140TolueneHCID 12192Ethyl diazoacetateHCID 670089234'-{[4-(trans-3-Hydroxycyclobutyl)-5-oxo-7-propyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl}biphenyl-2-carbonitrileHCID 178527705HCID 178527705, compound

Product 1

HCID 86644036ethyl [(cis-3-{6-[(2'-cyanobiphenyl-4-yl)methyl]-5-oxo-7-propyl[1,2,4]triazolo[1,5-a]pyrimidin-4(5H)-yl}cyclobutyl)oxy]acetate

Sources & evidence

ORD record
ord-282eedffceed4014998a7b6e3cbb9211
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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