Water → 4-Methyl-2-trifluoroacetyloxazole
Reaction equation
[F:1][C:2]([F:11])([F:10])[C:3](N1C=CN=C1)=[O:4].[CH3:12][C:13]1[N:14]=[C:15]([Si](C)(C)C)[O:16][CH:17]=1.O>C(OCC)C>[CH3:12][C:13]1[N:14]=[C:15]([C:3](=[O:4])[C:2]([F:11])([F:10])[F:1])[O:16][CH:17]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
1-Trifluoroacetylimidazole (10 g) was added to a stirred solution of 4-methyl-2-trimethylsilyloxazole (J. Chem. Soc., Chem. Commun., 1984, 258) (9.95 g) in diethyl ether (100 ml) at 0° C. After 20 hours, water was added. The organic phase was separated, dried and evaporated and the residue was purified by flash chromatography to give the title compound as the corresponding hydrate.
Workup
- customThe organic phase was separated
- customdried
- customevaporated
- customthe residue was purified by flash chromatography
Sources & evidence
- ORD record
- ord-0c8d181e4d924edba3ee1e5515808eb9
- Source dataset
- uspto-grants-1997_09
- Patent number
- US05665747
Reaction notes
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