trans-Crotonyl chloride → (4R)-3-((E)-2-butenoyl)-4-(phenylmethyl)-2-oxazolidinone

HRID 1378460

Reaction equation

HRID 1378460 reaction equation
[C:1](Cl)(=[O:5])/[CH:2]=[CH:3]/[CH3:4].[CH2:7]([C@@H:14]1[CH2:18][O:17][C:16](=[O:19])[NH:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[CH3:4]/[CH:3]=[CH:2]/[C:1]([N:15]1[C@H:14]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:18][O:17][C:16]1=[O:19])=[O:5]

Participants

3

Reactant 2

HCID 643131trans-Crotonyl chlorideHCID 2734969(R)-4-Benzyl-2-oxazolidinone

Product 1

HCID 11481966(4R)-3-((E)-2-butenoyl)-4-(phenylmethyl)-2-oxazolidinone

Procedure

trans-Crotonoyl chloride (Aldrich) was coupled with (R)-4-benzyl-2-oxazolidinone according to the procedure of Example 1c to afford the title compound.

Sources & evidence

ORD record
ord-95fa83ff60f24917b384b8eb0ee5a4bf
Source dataset
uspto-grants-1997_09
Patent number
US05668164

Linked notes

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