3-Cyano-2,6-dichloro-4-methylpyridine → 4-Methyl-3-cyanopyridine

HRID 1378689

Reaction equation

HRID 1378689 reaction equation
[C:1]([C:3]1[C:4](Cl)=[N:5][C:6](Cl)=[CH:7][C:8]=1[CH3:9])#[N:2]>[Pd](Cl)Cl.[Pd]>[C:1]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[CH3:9])#[N:2]

Participants

4

Reactant 1

HCID 701313-Cyano-2,6-dichloro-4-methylpyridine

Product 1

HCID 2278064-Methyl-3-cyanopyridine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 24290Palladium ChlorideCatalyst

Procedure

hydrogenating the 3-cyano-2,6-dichloro-4-methylpyridine produced in b) in the presence of an organic solvent, with an hydrogenation catalyst selected from the group consisting of palladium (II) chloride and 10% Pd/C, at 50 to 150 psi, at a temperature of from 20° C. to 100° C., for 6 to 24 hours, to produce 3-cyano-4-methylpyridine;

Workup

  1. customproduced in b) in the presence of an organic solvent

Sources & evidence

ORD record
ord-aec8da546a4b41c18a5b9393bce6e4e7
Source dataset
uspto-grants-1997_09
Patent number
US05668287

Linked notes

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